Fast-acting nasal spray to fight depression developed

Study confirms the efficacy of the new antidepressant

A new drug hope against severe depression. Esketamine nasal spray is designed to quickly and effectively relieve the symptoms of a severe Depression, when other antidepressants have failed. A recent study confirmed the safety and efficacy of the new antidepressants nasal sprays.

Around one third of Depression cannot be explained by common antidepressants to treat. A newly-developed drug can help alleviate, according to a recent study, such depression effectively. The fast-acting Esketamine nasal spray has now been successfully tested in around 200 adults with moderate to severe depression, in which at least two other antidepressants have failed. The results of the study were recently presented in the “American Journal of Psychiatry”.

Significant improvement in treatment-resistant depression

The Participants in the study were randomly divided into two groups. One group received an initiation of a new antidepressant (DULOXETINE, Escitalopram, sertraline, or venlafaxine) in combination with the new nasal spray. A second group also received a the initiated antidepressant and a Placebo nasal spray. After 28 days, the group with the Esketamine nasal aerosol showed significantly greater improvements than the placebo group.

First improvements within the first 24 hours

“This study shows that the adjuvant esketamine therapy is effective. The first improvements were already apparent within the first 24 hours ein“, the study’s author, Michael, As explained in a press release of the study results. The novel mechanism of action of Esketamine represents a significant development for the therapy of difficult-to-treat depression.

How safe is Esketamine nasal spray?

Some patients have reported side effects that occurred shortly after ingestion, but in the course of 90 minutes away. These include confusion, Nausea, dizziness and taste distortion included. Seven percent of the Participants in the study discontinued due to the side effects.

Specialist warns of potential for Abuse

In an accompanying commentary to the study, Dr. Alan schatzberg of Stanford University School of Medicine prior to the potential danger of Abuse of Esketamine warns. The effect is similar to the ketamine, that both for pain therapy as well as for depression is used. Due to its dissociative effect of ketamine will be used as a noise drug. Ketamine can cause a distortion of the space – and time perception, visual hallucinations, and out-of-body experiences. Treasure mountain fears that a nose could establish spray containing Esketamine as a new party drug.