The fountain of youth-CASIN slows down the aging processes
Always been a dream of the people of eternal youth, or at least a significant slowing down of the aging process. The substance of CASIN could be after a century long research, is now the key to success. According to a recent study in mice, the intake increased from CASIN the life expectancy of animals and so-called epigenetic clocks were turned back.
In search of possible substances that can bring about a rejuvenation at the cellular level, met with Researchers some time ago on CASIN. In the current study, the Team from the University of Ulm has studied at the University of Cincinnati, the Program of Regenerative Medicine, IDIBELL in Barcelona and at the RWTH Aachen in aged mice, the effects of CASIN. Their results were published in the journal “Aging Cell”.
Age-Associated Protein Cdc42
In previous studies it could be demonstrated that the activity of the Protein Cdc42 is increased in various organs and in the bone marrow betagterer mice, and also in the blood of older people, according to the research team. In the case of Cdc42 going to talk therefore of an age-associated Protein with premature aging and reduced service life in connection can be brought.
CASIN is a promising inhibitor
CASIN is to demonstrate an inhibitor for the reduction of this age-associated Protein (Cdc42-activity specific Inhibitor) and “in a previous work, we have already been able to that CASIN-old, blood-forming stem cells ,rejuvenate’, by the Cdc42 activity is reduced.”, study leader Professor Hartmut Geiger, Director of the Institute for Molecular medicine at the University of Ulm reported. After the treatment you have works just as well as young stem cells.
Attempts to gealteren mice
In the current study, the researchers re-examined to clearly aged mice, whether the short-term CASIN administration can extend the life of the animals, and what effects result for the so-called epigenetic clock. The 75-week-old female Mice (equivalent to about 60 – to 70-year-old humans) were given for this purpose, for four days, all 24 hours of CASIN.
Age-associated Protein Cdc42 inhibited
“In fact, the end was already one day after Treatment, a significant reduction in the activity of the age-associated Protein Cdc42 in the bone marrow of the animals to prove,” reports the University of Ulm of the research results. The Cdc42-level of the animals was in conformity with the clearly younger counterparts. In addition, the life expectancy in the case of the “pharmacologically rejuvenated” mice by up to ten per cent, had increased compared to their untreated counterparts.
Epigenetic clock turned back to 9 weeks
Nine weeks after the first Experiment, the research team has read also the so-called epigenetic watches in the blood cells of animals and also here after CASIN administration, significant changes are shown. The epigenetic clock of the treated rodents was turned back to about nine weeks, report the researchers. Thus, epigenetic changes seem to be the main cause of the increased life expectancy of the mice in CASIN-more are taking to the scientists.
Unique effect in spite of short-term ingestion
The CASIN-treated mice showed that the age-associated cytokines, a similar Serum levels as young animals. Generally, the findings suggest that CASIN “can prolong the lifespan of the mice even when your age is already very advanced, and when the substance is administered only briefly,” stresses the research team. If the effect on humans, could already extend a one-time treatment with CASIN at the age of about 60 years, life expectancy significantly. (fp)