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- The proportion of cells releasing neuropeptides was significantly lower in Alzheimer’s brains than in healthy brains.
- Neurons with the most neuropeptide activity—those releasing higher levels and greater diversity of neuropeptides—were disproportionately absent in Alzheimer’s brains.
- Increased age coincides with decreased neuropeptide activity in the hippocampus of Alzheimer’s brains, affecting an area of the brain that plays a major role in learning and memory.
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