Some people experience side effects when taking cannabidiol (CBD) oil and there are other things to consider before using CBD oil for pain.
In this article, we look at how CBD oil works and how it can be used to relieve chronic pain.
Cannabidiol, or CBD, is one of over 60 compounds called cannabinoids. Cannabinoids are found in many plants but are most commonly linked to cannabis.
Unlike other cannabinoids such as tetrahydrocannabinol (THC), CBD does not produce a euphoric “high” or psychoactive effect. This is because CBD does not affect the same receptors as THC.
The human body has an endocannabinoid system (ECS) that receives and translates signals it receives from cannabinoids in the body. The body produces some cannabinoids on its own, which are called endocannabinoids. The ECS helps regulate functions such as sleep, immune-system responses, and pain.
THC produces a “high” feeling by affecting the brain’s endocannabinoid receptors. This activates the brain’s reward system, producing pleasure chemicals such as dopamine.
CBD is an entirely different compound, and its effects are very complex. It is not psychoactive, meaning it does not produce a “high” or change a person’s state of mind. Instead, it influences the body to use its own endocannabinoids more effectively.
According to one study posted to Neurotherapeutics, this is because CBD itself does very little to the ECS. Instead, it activates or inhibits other compounds in the endocannabinoid system.
For instance, CBD stops the body from absorbing anandamide, one compound associated with regulating pain. Increased levels of anandamide in the bloodstream may reduce the amount of pain a person feels.
Cannabidiol may also limit inflammation in the brain and nervous system, which may help people experiencing pain, insomnia, and certain immune-system responses.
What is CBD oil?
There are different levels of compounds found in the natural hemp or cannabis plant. CBD levels vary depending on how the plant is bred. Most CBD oil comes from industrial hemp, which usually has a higher CBD content than marijuana.
Makers of CBD oil use different methods to extract the compound. The extract is then added to a carrier oil and called CBD oil. CBD oil comes in many different strengths and is used in various ways. It is best to discuss CBD oil with a qualified health care practitioner before using it.
A study in the European Journal of Pain used an animal model to see if CBD could help people with arthritis manage their pain. Researchers applied a topical gel containing CBD to rats with arthritis for 4 days.
Their research noted a significant drop in inflammation and signs of pain, without additional side effects.
People using CBD oil for arthritis may find relief from their pain, but more human studies need to be done to confirm these findings.
Multiple sclerosis (MS) is an autoimmune disease that affects the entire body through the nerves and brain.
Muscle spasms are one of the most common symptoms of MS. These spasms can be so great they cause constant pain in some people.
One report found that short-term use of CBD oil could reduce the levels of spasticity a person feels. The results are modest, but many people reported a reduction in symptoms. More human studies are needed to verify these results.
The same report studied CBD use for general chronic pain. Researchers compiled the results of multiple systematic reviews covering dozens of trials and studies. Their research concluded that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults.
A separate study in the Journal of Experimental Medicine supports these results. The research suggests pain and inflammation can be reduced through CBD use.
They also found that subjects were not likely to build up a tolerance to the effects of CBD, so they would not need to continually increase their dose. Researchers noted cannabinoids such as CBD could be a helpful new treatment for people with chronic pain.
Despite its varying legality across different states and at a Federal level, CBD oil has a range of current uses and promising possibilities.
- smoking cessation and drug withdrawal
- treating seizures and epilepsy
- anxiety treatment
- reducing some of the effects of Alzheimer’s, as shown by initial research
- antipsychotic effects on people with schizophrenia
- future applications in combating acne, type 1 diabetes, and cancer
Although more research is required to confirm some uses of CBD oil, it is shaping up as a promising and versatile treatment.
As CBD is not regulated by the United States Food and Drug Administration (FDA), dosages are currently open to interpretation and as such need to be approached with caution. Some companies advise dosages that are too high, and some recommend under-dosing.
However, a sensible dose to treat chronic pain is thought to be taking between 2.5 and 20 milligrams (mg) by mouth for no more than 25 days.
Due to the uncertain dosages, it is better to start with a low dosage and gradually increase it. If you begin to feel adverse effects, or you do not see any positive effects of this dosage after 25 days, speak to your doctor or practitioner.
CBD oil is well tolerated in most people, but there are some potential side effects. According to a review in Cannabis and Cannabinoid Research, the most common side effects include:
- changes in appetite
- weight gain or weight loss
Using CBD oil with other medications may make those medications more or less effective. People who are considering using CBD oil should discuss this with their doctors. Doctors will want to monitor the person for any changes and make adjustments accordingly.
The review also noted there are some aspects of CBD that have yet to be studied, such as the long-term effects of CBD use on hormones. Other long-term studies will be helpful in determining any side effects CBD has on the body over time.
CBD and other cannabinoids may also put the user at risk for lung problems. One study in Frontiers in Pharmacology, suggested cannabinoids’ anti-inflammatory effect may reduce inflammation too much.
A large reduction in inflammation could diminish the lungs’ defence system, increasing the risk of infection.
Almost all research on CBD oil and pain comes from adult use. CBD oil is not recommended for use in children, as there is little research on the effects of CBD oil on a child’s developing brain. It is also not recommended for pregnant or breast-feeding women.
While many studies have suggested CBD oil is helpful for pain, more research is needed, especially long-term studies with human subjects.
However, CBD oil does show a lot of potential for pain relief. If anecdotal evidence is to be believed, it can be used to help manage chronic pain in many cases.
CBD oil is especially promising due to its lack of intoxicating effects and a possible lower potential for side effects than many other pain medications. CBD oil is available to purchase online. A person should discuss CBD oil with their doctor before starting to use it.
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